Article

Investigation into the role of LSH ATPase in chromatin remodelling

2020-01-01

Abstract excerpt

Chromatin remodelling is a crucial nuclear process affecting replication, transcription and repair. Global reduction of DNA methylation is observed in Immunodeficiency-Centromeric Instability-Facial Anomaly (ICF) syndrome. Several proteins were found to be mutated in patients diagnosed with ICF, among them are LSH and CDCA7. LSH is a chromatin remodeller bearing homology to the members of Sf2 remodelling family. A...

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Literature Corpus work: 4278eeae-0c80-515c-8830-5e4fe75cb800
DOI: 10.7488/era/138

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