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Article

Dissecting molecular steps in chromatin domain activation during hematopoietic differentiation.

Molecular and cellular biology - 1 Jun 2007

Kim Shin-Il, Bultman Scott J, Jing Huie, Blobel Gerd A, Bresnick Emery H

Abstract excerpt

GATA factors orchestrate hematopoiesis via multistep transcriptional mechanisms, but the interrelationships and importance of individual steps are poorly understood. Using complementation analysis with GATA-1-null cells and mice containing a hypomorphic allele of the chromatin remodeler BRG1, we dissected the pathway from GATA-1 binding to cofactor recruitment, chromatin loop formation, and transcriptional...

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Identifiers

PMID: 17438135
DOI: 10.1128/MCB.00235-07
PMCID: PMC1900038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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