Article
Phe217 regulates the transfer of allosteric information across the subunit interface of the RecA protein filament.
Structure (London, England : 1993) - 10 Jan 2001
Kelley De Zutter J, Forget A L, Logan K M, Knight K L
Abstract excerpt
BACKGROUND: ATP-mediated cooperative assembly of a RecA nucleoprotein filament activates the protein for catalysis of DNA strand exchange. RecA is a classic allosterically regulated enzyme in that ATP binding results in a dramatic increase in ssDNA binding affinity. This increase in ssDNA binding...
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