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Article

IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells

26 Mar 2015

Abstract excerpt

Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are associated with disease-initiating stem cells that are not eliminated by conventional therapies. Novel therapeutic targets against preleukemic stem cells need to be identified for potentially curative strategies. We conducted parallel transcriptional analysis of highly fractionated stem and progenitor populations in MDS, AML, and control samples...

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PMID: 25810490
DOI: 10.1182/blood-2015-01-621631

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