Article

CXCR2 As a Novel Target for Overcoming Resistance to Tyrosine Kinase Inhibitors in Chronic Myelogenous Leukemia Cells

2021-01-25

Abstract excerpt

<h4>Background: </h4> Chronic myeloid leukemia (CML) is a reciprocal translocation disorder driven by a breakpoint cluster region ( BCR )-Abelson leukemia virus ( ABL ) fusion gene that stimulates abnormal tyrosine kinase activity. Tyrosine kinase inhibitors (TKIs) are effective in the treatment of Philadelphia chromosome (Ph) + CML patients. However, the appearance of TKI-resistant CML cells is a hurdle in CML tr...

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Literature Corpus work: 22fcf7b4-6410-51e8-9a6a-54718b55e6fe
DOI: 10.21203/rs.3.rs-152459/v1

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