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Leukemia Stem Cells and Microenvironment: Biology and Therapeutic Targeting

11 Jan 2011

Abstract excerpt

Acute myelogenous leukemia is propagated by a subpopulation of leukemia stem cells (LSCs). In this article, we review both the intrinsic and extrinsic components that are known to influence the survival of human LSCs. The intrinsic factors encompass regulators of cell cycle and prosurvival pathways (such as nuclear factor kappa B [NF-κB], AKT), pathways regulating oxidative stress, and specific molecular...

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Share to Acute Myeloid Leukemia Research
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Identifiers

PMID: 21220598
DOI: 10.1200/jco.2010.31.0904

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