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Article

CXCR4 as a therapeutic target in acute myeloid leukemia.

Leukemia - 1 Nov 2024

Korbecki Jan, Bosiacki Mateusz, Kupnicka Patrycja, Barczak Katarzyna, Chlubek Dariusz, Baranowska-Bosiacka Irena

Abstract excerpt

Extensive research on the CXCL12-CXCR4 axis in acute myeloid leukemia (AML) has resulted in the incorporation of novel anti-leukemia drugs targeting this axis into therapeutic strategies. However, despite this progress, a comprehensive and up-to-date review addressing the role of the CXCL12-CXCR4 axis in AML's oncogenic processes is lacking. In this review, we examine its molecular aspects influencing cancer...

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Topics

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Share to Antineoplastic Agents
Share to Chemokine CXCL12
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Molecular Targeted Therapy

Share to Mutation

Share to Nucleophosmin

Share to Receptors, CXCR4

Source

Identifiers

PMID: 39261603
DOI: 10.1038/s41375-024-02326-3

Genes

CXCR4
CXCL12
FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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