A maximum kernel-based association test to detect the pleiotropic genetic effects on multiple phenotypes.

doi:10.1093/bioinformatics/btad291

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Article

A maximum kernel-based association test to detect the pleiotropic genetic effects on multiple phenotypes.

Bioinformatics (Oxford, England) - 4 May 2023

Wang Jinjuan, Long Mingya, Li Qizhai

Abstract excerpt

MOTIVATION: Testing the association between multiple phenotypes with a set of genetic variants simultaneously, rather than analyzing one trait at a time, is receiving increasing attention for its high statistical power and easy explanation on pleiotropic effects. The kernel-based association test (KAT), being free of data dimensions and structures, has proven to be a good alternative method for genetic...

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PMID: 37104737
DOI: 10.1093/bioinformatics/btad291
PMCID: PMC10174706

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