rs1801133C>T polymorphism in MTHFR is a risk factor for nonsyndromic cleft lip with or without cleft palate in the Brazilian population.

doi:10.1002/bdra.23365

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Article

rs1801133C>T polymorphism in MTHFR is a risk factor for nonsyndromic cleft lip with or without cleft palate in the Brazilian population.

Birth defects research. Part A, Clinical and molecular teratology - 1 Apr 2015

de Aguiar Pamella Kelly Farias, Coletta Ricardo D, de Oliveira Allane Maria Lacerda Ferreira, Machado Renato Assis, Furtado Paulo Germano Cavalcante, de Oliveira Lindalva Alves, de Aquino Sibele Nascimento, Martelli-Junior Hercilio, de Almeida Reis Silvia Regina, Moreira Helenara Salvati Bertolossi, Persuhn Darlene Camati

Abstract excerpt

BACKGROUND: The MTHFR rs1801131A>C and rs1801133C>T variants have been analyzed as putative genetic risk factors for oral clefts within various populations worldwide. METHODS: To test the role of these polymorphisms in nonsyndromic cleft lip with or without cleft palate (NSCL/P) in the Brazilian population, we conducted a study combining a Family-Based Association Test (transmission disequilibrium test) and a...

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PMID: 25808365
DOI: 10.1002/bdra.23365

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MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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