Article
Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells.
International journal of cancer - 1 Oct 2015
de Vrij Jeroen, Maas S L Niek, Kwappenberg Kitty M C, Schnoor Rosalie, Kleijn Anne, Dekker Lennard, Luider Theo M, de Witte Lot D, Litjens Manja, van Strien Miriam E, Hol Elly M, Kroonen Jerome, Robe Pierre A, Lamfers Martine L, Schilham Marco W, Broekman Marike L D
Abstract excerpt
Glioblastoma multiforme (GBM) is the most common primary brain tumor and is without exception lethal. GBMs modify the immune system, which contributes to the aggressive nature of the disease. Particularly, cells of the monocytic lineage, including monocytes, macrophages and microglia, are affected. We investigated the influence of GBM-derived extracellular vesicles (EVs) on the phenotype of monocytic cells....
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