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Article

Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 5 Jan 2018

Oushy Soliman, Hellwinkel Justin E, Wang Mary, Nguyen Ger J, Gunaydin Dicle, Harland Tessa A, Anchordoquy Thomas J, Graner Michael W

Abstract excerpt

Glioblastoma multiforme (GBM) is a devastating tumour with abysmal prognoses. We desperately need novel approaches to understand GBM biology and therapeutic vulnerabilities. Extracellular vesicles (EVs) are membrane-enclosed nanospheres released locally and systemically by all cells, including tumours, with tremendous potential for intercellular communication. Tumour EVs manipulate their local environments as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29158308
DOI: 10.1098/rstb.2016.0477
PMCID: PMC5717433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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