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Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease

21 Oct 2016

Abstract excerpt

Extracellular vesicles (EVs) play key roles in glioblastoma (GBM) biology and represent novel sources of biomarkers that are detectable in the peripheral circulation. Despite this notionally non-invasive approach to assess GBM tumours in situ, a comprehensive GBM EV protein signature has not been described. Here, EVs secreted by six GBM cell lines were isolated and analysed by quantitative high-resolution mass...

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PMID: 27770278
DOI: 10.1007/s11060-016-2298-3

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