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ERK1/2 signaling regulates the immune microenvironment and macrophage recruitment in glioblastoma

29 Aug 2019

Abstract excerpt

The tumor microenvironment is an important determinant of glioblastoma (GBM) progression and response to treatment. How oncogenic signaling in GBM cells modulates the composition of the tumor microenvironment and its activation is unclear. We aimed to explore the potential local immunoregulatory function of ERK1/2 signaling in GBM. Using proteomic and transcriptomic data (RNA seq) available for GBM tumors from...

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PMID: 31467175
DOI: 10.1042/bsr20191433

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