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Article

FBXO4 loss facilitates carcinogen induced papilloma development in mice.

Cancer biology & therapy - 1 Jan 2015

Lian Zhaorui, Lee Eric K, Bass Adam J, Wong Kwok K, Klein-Szanto Andres Jp, Rustgi Anil K, Diehl J Alan

Abstract excerpt

Cyclin D1 is frequently overexpressed in esophageal squamous cell carcinoma (ESCC) and is considered a key driver of this disease. Mutations in FBXO4, F-box specificity factor that directs SCF-mediated ubiquitylation of cyclin D1, occur in ESCC with concurrent overexpression of cyclin D1 suggesting a potential tumor suppressor role for FBXO4. To evaluate the contribution of FBXO4-dependent regulation cyclin D1 in...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25801820
DOI: 10.1080/15384047.2015.1026512
PMCID: PMC4622573

Genes

FBXO4
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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