Article
Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer.
Cancer research - 1 Feb 2004
Ekholm-Reed Susanna, Spruck Charles H, Sangfelt Olle, van Drogen Frank, Mueller-Holzner Elisabeth, Widschwendter Martin, Zetterberg Anders, Reed Steven I, Reed Susanna Ekholm
Abstract excerpt
hCDC4, the gene that encodes the F-box protein responsible for targeting cyclin E for ubiquitin-mediated proteolysis, has been found to be mutated in a number of primary cancers and cancer-derived cell lines. We have observed that functional inactivation of hCDC4 does not necessarily correlate with elevated levels of cyclin E in tumors. Here we show, however, that hCDC4 mutation in primary tumors correlates...
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