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Article

DNA polymerase β deficiency promotes the occurrence of esophageal precancerous lesions in mice.

Neoplasia (New York, N.Y.) - 1 Jul 2021

Qin Jiace, Zhu Yanyan, Ding Yongwei, Niu Tingting, Zhang Yangyang, Wu Huiting, Zhu Lili, Yuan Baoyin, Qiao Yan, Lu Jing, Liu Kangdong, Dong Ziming, Jin Ge, Chen Xinhuan, Zhao Jimin

Abstract excerpt

Esophageal mucosa undergoes mild, moderate, severe dysplasia, and other precancerous lesions and eventually develops into carcinoma in situ, and understanding the developmental progress of esophageal precancerous lesions is beneficial to prevent them from developing into cancer. DNA polymerase β (Polβ), a crucial enzyme of the base excision repair system, plays an important role in repairing damaged DNA and...

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Identifiers

PMID: 34144266
DOI: 10.1016/j.neo.2021.05.001
PMCID: PMC8217306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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