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Article

Cyclin D1 overexpression increases susceptibility to 4-nitroquinoline-1-oxide-induced dysplasia and neoplasia in murine squamous oral epithelium.

Molecular carcinogenesis - 1 Sept 2009

Wilkey Jonathan F, Buchberger Glenn, Saucier Kirsten, Patel Salony M, Eisenberg Ellen, Nakagawa Hiroshi, Michaylira Carmen Z, Rustgi Anil K, Mallya Sanjay M

Abstract excerpt

The cyclin D1 oncogene is frequently amplified/overexpressed in oral squamous cell carcinomas. Mice with overexpression of cyclin D1 targeted to the stratified squamous epithelia of the tongue, esophagus, and forestomach develop a phenotype of epithelial dysplasia at these sites. In this study, we examined the effect of cyclin D1 overexpression on susceptibility of mice to carcinogen-induced tumorigenesis, using...

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Source

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Identifiers

PMID: 19263437
DOI: 10.1002/mc.20531
PMCID: PMC2736315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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