Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synergistic function of Smad4 and PTEN in suppressing forestomach squamous cell carcinoma in the mouse.

Cancer research - 15 Jul 2006

Teng Yan, Sun An-Na, Pan Xiao-Chen, Yang Guan, Yang Lei-Lei, Wang Ming-Rong, Yang Xiao

Abstract excerpt

The genetic bases underlying esophageal tumorigenesis are poorly understood. Our previous studies have shown that coordinated deletion of the Smad4 and PTEN genes results in accelerated hair loss and skin tumor formation in mice. Herein, we exemplify that the concomitant inactivation of Smad4 and PTEN accelerates spontaneous forestomach carcinogenesis at complete penetrance during the first 2 months of age. All...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Growth Processes
Share to Cyclin D
Share to Cyclins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Esophageal Neoplasms

Share to Keratins

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

Share to Smad4 Protein

Source

Identifiers

PMID: 16849541
DOI: 10.1158/0008-5472.CAN-06-0507

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synergistic function of Smad4 and PTEN in suppressing forestomach squamous cell carcinoma in the mouse.PMID 16849541Read ↗

Targeted Disruption of Smad4 in Mouse Epidermis Results in Failure of Hair Follicle Cycling and Formation of Skin TumorsSemantic proximity Read ↗

Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice.Semantic proximity Read ↗

Smad4-mediated TGF-β signaling in tumorigenesisSemantic proximity Read ↗

Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammationSemantic proximity Read ↗

A platform of functional studies of ESCC-associated gene mutations identifies the roles of TGFBR2 in ESCC progression and metastasis.Semantic proximity Read ↗

Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progressionSemantic proximity Read ↗

Crosstalk between Pten and Ras signaling pathways in tumor development.Semantic proximity Read ↗

Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.Semantic proximity Read ↗

Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice.Semantic proximity Read ↗

An effective multistage mouse model of esophageal carcinogenesis for preclinical and computational pathology applications.Semantic proximity Read ↗

Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma.Semantic proximity Read ↗

PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.