Article
A transgenic mouse model with cyclin D1 overexpression results in cell cycle, epidermal growth factor receptor, and p53 abnormalities.
Cancer research - 15 Dec 1997
Mueller A, Odze R, Jenkins T D, Shahsesfaei A, Nakagawa H, Inomoto T, Rustgi A K
Abstract excerpt
The cyclin D1 oncogene is critical in the progression of the cell cycle through the G1 phase. It is frequently overexpressed in squamous cell carcinomas originating from the head/neck and esophagus. Yet, the functional consequences of aberrant cyclin D1 overexpression are not entirely understood...
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