Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues.

Molecular and cellular biology - 1 Sept 2004

Miliani de Marval Paula L, Macias Everardo, Rounbehler Robert, Sicinski Piotr, Kiyokawa Hiroaki, Johnson David G, Conti Claudio J, Rodriguez-Puebla Marcelo L

Abstract excerpt

The proto-oncogene c-myc encodes a transcription factor that is implicated in the regulation of cellular proliferation, differentiation, and apoptosis and that has also been found to be deregulated in several forms of human and experimental tumors. We have shown that forced expression of c-myc in epithelial tissues of transgenic mice (K5-Myc) resulted in keratinocyte hyperproliferation and the development of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase 4
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Cyclin-Dependent Kinases

Share to Cyclins

Share to Epidermal Cells

Share to Epidermis

Share to Proto-Oncogene Proteins c-myc

Source

Open in PubMed Open full text

Identifiers

PMID: 15314163
DOI: 10.1128/MCB.24.17.7538-7547.2004
PMCID: PMC506988

Genes

CDK4
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues.PMID 15314163Read ↗

Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epithelium.Semantic proximity Read ↗

Myc lacks E2F1's ability to suppress skin carcinogenesis.Semantic proximity Read ↗

Targeting Cyclins and Cyclin-Dependent Kinases in Cancer: Lessons from Mice, Hopes for Therapeutic Applications in HumansSemantic proximity Read ↗

CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development.Semantic proximity Read ↗

c-MYC: more than just a matter of life and death.Semantic proximity Read ↗

Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases.Semantic proximity Read ↗

E2F2 suppresses Myc‐induced proliferation and tumorigenesisSemantic proximity Read ↗

Deregulated CDC25A Expression Promotes Mammary Tumorigenesis with Genomic InstabilitySemantic proximity Read ↗

Inactivation of E2f1 enhances tumorigenesis in a Myc transgenic model.Semantic proximity Read ↗

The c-MYC oncoprotein as a treatment target in cancer and other disorders of cell growthSemantic proximity Read ↗

Conditional expression and oncogenicity of c-myc linked to a CD2 gene dominant control region.Semantic proximity Read ↗

Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.