Ablation of Proliferating Osteoblast Lineage Cells After Fracture Leads to Atrophic Nonunion in a Mouse Model

Abstract excerpt

<h4>ABSTRACT</h4> Nonunion is defined as the permanent failure of a fractured bone to heal, often necessitating surgical intervention. Atrophic nonunions are a subtype that are particularly difficult to treat. Animal models of atrophic nonunion are available; however, these require surgical or radiation-induced trauma to disrupt periosteal healing. These methods are invasive and not representative of many clinica...

Topics

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• Bone and Bones
• Bone fractures and treatments
• Bone health and treatments
• Bone Metabolism and Diseases
• Cartilage
• Chondrocytes
• Core Binding Factor Alpha 2 Subunit
• Dose-Response Relationship, Drug

Identifiers and source

Literature Corpus work

a2af37cb-abbb-5287-b572-be83c67dcef7

DOI

10.1101/2020.10.06.327288