Article
Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice.
PloS one - 1 Jan 2014
Rodríguez-de la Rosa Lourdes, López-Herradón Ana, Portal-Núñez Sergio, Murillo-Cuesta Silvia, Lozano Daniel, Cediel Rafael, Varela-Nieto Isabel, Esbrit Pedro
Abstract excerpt
Insulin-like growth factor-I (IGF-I) deficiency causes growth delay, and IGF-I has been shown to partially mediate bone anabolism by parathyroid hormone (PTH). PTH-related protein (PTHrP) is abundant in bone, and has osteogenic features by poorly defined mechanisms. We here examined the capacity of PTHrP (1-36) and PTHrP (107-111) (osteostatin) to reverse the skeletal alterations associated with IGF-I deficiency....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.