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Article

Adenovirus vector-based in vitro neuronal cell model for Huntington's disease with human disease-like differential aggregation and degeneration.

The journal of gene medicine - 1 Jul 2012

Dong Xiaomin, Zong Shan, Witting Anke, Lindenberg Katrin S, Kochanek Stefan, Huang Bin

Abstract excerpt

BACKGROUND: Neuronal degeneration, in particular in the striatum, and the formation of nuclear and cytoplasmic inclusions are characteristics of Huntington's disease (HD) as a result of the expansion of a polyglutamine tract located close to the N-terminus of huntingtin (htt). Because of the large (10-kb) size of the htt cDNA, expression of full-length htt in primary neurons has proved difficult in the past....

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PMID: 22700462
DOI: 10.1002/jgm.2641

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