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Article

FAT1 is a novel upstream regulator of HIF1α and invasion of high grade glioma

18 Aug 2016

Abstract excerpt

The hypoxic microenvironment is an important contributor of glioblastoma (GBM) aggressiveness via HIF1α, while tumour inflammation is profoundly influenced by FAT Atypical Cadherin (FAT1). This study was designed to explore the functional interaction and significance of FAT1 and HIF1α under severe hypoxia-mimicking tumour microenvironment in primary human tumours. We first identified a positive correlation of...

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PMID: 27536856
DOI: 10.1002/ijc.30386

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