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Article

The effects of BMP2 and the mechanisms involved in the invasion and angiogenesis of IDH1 mutant glioma cells.

Journal of neuro-oncology - 1 Oct 2024

Xu Hui, Cao Yu, Ruan Jianqiao, Wang Fei, He Yuhong, Yang Lina, Yu Tian, Du Fang, Zhang Ningmei, Cao Xiangmei

Abstract excerpt

PURPOSE: This study investigated the effect of an isocitrate dehydrogenase 1 (IDH1) mutation (mutIDH1) on the invasion and angiogenesis of human glioma cells. METHODS: Doxycycline was used to induce the expression of mutIDH1 in glioma cells. Transwell and wound healing assays were conducted to assess glioma cell migration and invasion. Western blotting and cell immunofluorescence were used to measure the...

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Identifiers

PMID: 39117967
DOI: 10.1007/s11060-024-04789-x
PMCID: PMC11447149

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