Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Astrocyte elevated gene 1: biological functions and molecular mechanism in cancer and beyond

1 Nov 2011

Abstract excerpt

Since its discovery, nearly one decade of research on astrocyte elevated gene 1 (AEG-1) has witnessed expanding knowledge of this molecule, ranging from its role in cancer biology to molecular mechanisms underlying the biological functions. As a multifunctional oncoprotein, AEG-1 has been shown to overexpress in multiple types of human cancer, and the elevation of AEG-1 in tumor cells leads to enhanced phenotypes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Mechanisms of cancer metastasis
Share to Peptidase Inhibition and Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22060137
DOI: 10.1186/2045-3701-1-36

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Astrocyte elevated gene 1: biological functions and molecular mechanism in cancer and beyondPMID 22060137Read ↗

Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosisSemantic proximity Read ↗

Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progressionSemantic proximity Read ↗

The Scope of Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Cancer Clinicopathology: A ReviewSemantic proximity Read ↗

Astrocyte Elevated Gene-1 Interacts with Akt Isoform 2 to Control Glioma Growth, Survival, and PathogenesisSemantic proximity Read ↗

Interaction with AEG-1 and MDM2 is associated with glioma development and progression and correlates with poor prognosisSemantic proximity Read ↗

Astrocyte elevated gene-1 is associated with metastasis in head and neck squamous cell carcinoma through p65 phosphorylation and upregulation of MMP1Semantic proximity Read ↗

Astrocyte Elevated Gene 1 Interacts with Acetyltransferase p300 and c-Jun To Promote Tumor AggressivenessSemantic proximity Read ↗

Multifunctional Role of Astrocyte Elevated Gene-1 (AEG-1) in Cancer: Focus on Drug ResistanceSemantic proximity Read ↗

Knockdown of astrocyte elevated gene-1 inhibits tumor growth and modifies microRNAs expression profiles in human colorectal cancer cellsSemantic proximity Read ↗

Activation of the Nuclear Factor κB Pathway by Astrocyte Elevated Gene-1: Implications for Tumor Progression and MetastasisSemantic proximity Read ↗

Molecular Mechanism of Chemoresistance by Astrocyte Elevated Gene-1Semantic proximity Read ↗

Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH): A Promising Molecular Marker and Therapeutic Target for Hepatocellular CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.