Article
Knock-out of CD73 delays the onset of HR-negative breast cancer by reprogramming lipid metabolism and is associated with increased tumor mutational burden.
Molecular metabolism - 1 Nov 2024
Serafin Paweł Kamil, Popęda Marta, Bulak Kamila, Zwara Agata, Galikowska-Bogut Barbara, Przychodzka Anna, Mika Adriana, Śledziński Tomasz, Stanisławowski Marcin, Jendernalik Kamila, Bolcewicz Marika, Laprus Wiktoria, Stasiłojć Grzegorz, Sądej Rafał, Żaczek Anna, Kalinowski Leszek, Koszałka Patrycja
Abstract excerpt
OBJECTIVE: CD73 (ecto-5'-nucleotidase, NT5E), a cell-surface enzyme converting 5'-AMP to adenosine, is crucial for cancer progression. However, its role in the tumorigenesis process remains mostly obscure. We aimed to demonstrate CD73's role in breast cancer (BC) tumorigenesis through metabolic rewiring of fatty acid metabolism, a process recently indicated to be regulated by BC major prognostic markers, hormone...
Topics
Join the communities discussing this publication.