Mapping of a quantitative trait locus controlling susceptibility to Coxsackievirus B3-induced viral hepatitis.

doi:10.1038/gene.2015.5

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Article

Mapping of a quantitative trait locus controlling susceptibility to Coxsackievirus B3-induced viral hepatitis.

Genes and immunity - 1 Jun 2015

Wiltshire S A, Marton J, Leiva-Torres G A, Vidal S M

Abstract excerpt

The pathogenesis of coxsackieviral infection is a multifactorial process involving host genetics, viral genetics and the environment in which they interact. We have used a mouse model of Coxsackievirus B3 infection to characterize the contribution of host genetics to infection survival and to viral hepatitis. Twenty-five AcB/BcA recombinant congenic mouse strains were screened. One, BcA86, was found to be...

Topics

Alanine Transaminase
Animals
Coxsackievirus Infections
Enterovirus B, Human
Genetic Linkage
Genetic Predisposition to Disease
Hepatitis, Viral, Animal
Interferon Type I
Mice, Inbred C57BL
Mice, Inbred Strains
Quantitative Trait Loci

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Open in PubMed

Identifiers

PMID: 25790079
DOI: 10.1038/gene.2015.5

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