Article
Novel nonmajor histocompatibility complex-linked loci from mouse chromosome 17 confer susceptibility to viral-mediated chronic autoimmune myocarditis.
Circulation. Cardiovascular genetics - 1 Oct 2010
Poffenberger Maya C, Shanina Iryna, Aw Connie, El Wharry Nahida, Straka Nadine, Fang Dianne, Baskin-Hill Annie E, Spiezio Sabrina H, Nadeau Joseph H, Horwitz Marc S
Abstract excerpt
BACKGROUND: Development of viral-induced chronic myocarditis is thought to involve both environmental and genetic factors. However, to date, no susceptibility genes have been identified. METHODS AND RESULTS: We sought to identify loci that confer susceptibility to viral-induced chronic myocarditis with the use of chromosome substitution strain mice that are composed of 1 chromosome from the disease susceptible...
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