Article
Identification of multiple genetic loci that regulate adenovirus gene therapy.
Gene therapy - 1 Jan 2004
Zhang H-G, Hsu H-C, Yang P-A, Yang X, Wu Q, Liu Z, Yi N, Mountz J D
Abstract excerpt
A key aspect of the immune response to adenovirus (Ad) gene therapy is the generation of a cytotoxic T-cell (CTL) response. To better understand the genetic network underlying these events, 20 strains of C57BL/6 x DBA/2 (BXD) recombinant inbred (RI) mice were administered with AdLacZ and analyzed at days 7, 21, 30, and 50 for liver beta-galactosidase (LacZ) expression and CTL response. Sera levels of interferon...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.