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Article

Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor.

Cell cycle (Georgetown, Tex.) - 1 Jan 2015

Portela Marta, Parsons Linda M, Grzeschik Nicola A, Richardson Helena E

Abstract excerpt

The evolutionarily conserved neoplastic tumor suppressor protein, Lethal (2) giant larvae (Lgl), plays roles in cell polarity and tissue growth via regulation of the Hippo pathway. In our recent study, we showed that in the developing Drosophila eye epithelium, depletion of Lgl leads to increased ligand-dependent Notch signaling. lgl mutant tissue also exhibits an accumulation of early endosomes, recycling...

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Identifiers

PMID: 25789785
DOI: 10.1080/15384101.2015.1026515
PMCID: PMC4613855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor.PMID 25789785Read ↗

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