Article

OCRL regulates lysosomal function and endolysosomal homeostasis in Drosophila nephrocytes

2025-12-03

Abstract excerpt

The OCRL gene encodes a lipid phosphatase that dephosphorylates phosphatidylinositol 4,5 bisphosphate [(PI4,5)P2]. Mutations in OCRL lead to a rare human genetic disorder, Lowe syndrome (LS) that affects the eye, kidney and brain. OCRL is widely expressed in cells and is localized to multiple organelles, including the plasma membrane, endosomes, Golgi and lysosomes. Although multiple defects in the endo-lysosomal...

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Literature Corpus work: ed421df5-f467-5df1-9abf-4fc0f2a86312
DOI: 10.64898/2025.12.03.692239

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