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Article

Activation of Notch in lgd mutant cells requires the fusion of late endosomes with the lysosome.

Journal of cell science - 15 Jan 2013

Schneider Markus, Troost Tobias, Grawe Ferdi, Martinez-Arias Alfonso, Klein Thomas

Abstract excerpt

The tumour suppressor Lethal (2) giant discs (Lgd) is a regulator of endosomal trafficking of the Notch signalling receptor as well as other transmembrane proteins in Drosophila. The loss of its function results in an uncontrolled ligand-independent activation of the Notch signalling receptor. Here, we investigated the consequences of loss of lgd function and the requirements for the activation of Notch. We show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23178945
DOI: 10.1242/jcs.116590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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