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Article

The tumour suppressor Lethal (2) giant discs is required for the function of the ESCRT-III component Shrub/CHMP4.

Journal of cell science - 1 Feb 2012

Troost Tobias, Jaeckel Sandra, Ohlenhard Nadja, Klein Thomas

Abstract excerpt

Recent work indicates that defects in late phases of the endosomal pathway caused by loss of function of the tumour suppressor gene lethal (2) giant discs (lgd) or the function of the ESCRT complexes I-III result in the ligand-independent activation of the Notch pathway in all imaginal disc cells in Drosophila melanogaster. lgd encodes a member of an uncharacterised protein family, whose members contain one C2...

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Identifiers

PMID: 22389409
DOI: 10.1242/jcs.097261

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