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Article

Identification of a Master Regulator of Differentiation in Toxoplasma

1 Jan 2020

Abstract excerpt

Toxoplasma gondii chronically infects a quarter of the world's population, and its recrudescence can cause life-threatening disease in immunocompromised individuals and recurrent ocular lesions in the immunocompetent. Acute-stage tachyzoites differentiate into chronic-stage bradyzoites, which form intracellular cysts resistant to immune clearance and existing therapies. The molecular basis of this differentiation...

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PMID: 31955846
DOI: 10.1016/j.cell.2019.12.013

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