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Toxoplasma gondii Cyclic AMP-Dependent Protein Kinase Subunit 3 Is Involved in the Switch from Tachyzoite to Bradyzoite Development.

mBio - 31 May 2016

Sugi Tatsuki, Ma Yan Fen, Tomita Tadakimi, Murakoshi Fumi, Eaton Michael S, Yakubu Rama, Han Bing, Tu Vincent, Kato Kentaro, Kawazu Shin-Ichiro, Gupta Nishith, Suvorova Elena S, White Michael W, Kim Kami, Weiss Louis M

Abstract excerpt

UNLABELLED: Toxoplasma gondii is an obligate intracellular apicomplexan parasite that infects warm-blooded vertebrates, including humans. Asexual reproduction in T. gondii allows it to switch between the rapidly replicating tachyzoite and quiescent bradyzoite life cycle stages. A transient cyclic AMP (cAMP) pulse promotes bradyzoite differentiation, whereas a prolonged elevation of cAMP inhibits this process. We...

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Identifiers

PMID: 27247232
DOI: 10.1128/mBio.00755-16
PMCID: PMC4895117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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