Article
High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei.
Eukaryotic cell - 1 Mar 2014
MacGregor Paula, Ivens Alasdair, Shave Steven, Collie Iain, Gray David, Auer Manfred, Matthews Keith R
Abstract excerpt
In the bloodstream of mammalian hosts, the sleeping sickness parasite, Trypanosoma brucei, exists as a proliferative slender form or a nonproliferative, transmissible, stumpy form. The transition between these developmental forms is controlled by a density-dependent mechanism that is important for the parasite's infection dynamics, immune evasion via ordered antigenic variation, and disease transmissibility....
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