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Article

CDPK2A and CDPK1 form a signaling module upstream of Toxoplasma motility

23 Aug 2023

Abstract excerpt

ABSTRACT In apicomplexan parasites, the transition between replication and dissemination is regulated by fluctuations in cytosolic calcium concentrations, transduced in part by calcium-dependent protein kinases (CDPKs). We examined the role of CDPK2A in the lytic cycle of Toxoplasma , analyzing its role in the regulation of cellular processes associated with parasite motility. We used chemical-genetic approaches...

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PMID: 37610220
DOI: 10.1128/mbio.01358-23

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