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Article

Genetic support for the role of the NLRP3 inflammasome in psoriasis susceptibility.

Experimental dermatology - 1 Dec 2012

Carlström Maria, Ekman Anna-Karin, Petersson Stina, Söderkvist Peter, Enerbäck Charlotta

Abstract excerpt

NACHT leucine-rich repeat- and PYD-containing (NLRP)3 protein controls the inflammasome by regulating caspase-1 activity and interleukin (IL)-1β processing. The contribution of IL-1β in the pathogenesis of psoriasis is well recognized. Polymorphisms in NLRP3 and caspase recruitment domain-containing protein (CARD)8, a negative regulator of caspase-1 activity, have been associated with susceptibility to common...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23171454
DOI: 10.1111/exd.12049

Genes

NLRP3
CARD8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Genetic support for the role of the NLRP3 inflammasome in psoriasis susceptibility.PMID 23171454Read ↗

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Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.Semantic proximity Read ↗

NLRP3 (rs10754558) gene polymorphism and tumor necrosis factor alpha as predictors for disease activity and response to methotrexate and adalimumab in psoriasis.Semantic proximity Read ↗

Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease.Semantic proximity Read ↗

NLRP3 inflammasome (rs10754558) gene polymorphism in patients with atopic dermatitis.Semantic proximity Read ↗

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Genetics of inflammasome-associated disorders: a lesson in the guiding principals of inflammasome function.Semantic proximity Read ↗

Genetic variants in CARD8 but not in NLRP3 are associated with ankylosing spondylitis.Semantic proximity Read ↗

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