Article
KCNQ1 gain-of-function mutation in familial atrial fibrillation.
Science (New York, N.Y.) - 10 Jan 2003
Chen Yi-Han, Xu Shi-Jie, Bendahhou Said, Wang Xiao-Liang, Wang Ying, Xu Wen-Yuan, Jin Hong-Wei, Sun Hao, Su Xiao-Yan, Zhuang Qi-Nan, Yang Yi-Qing, Li Yue-Bin, Liu Yi, Xu Hong-Ju, Li Xiao-Fei, Ma Ning, Mou Chun-Ping, Chen Zhu, Barhanin Jacques, Huang Wei
Abstract excerpt
Atrial fibrillation (AF) is a common cardiac arrhythmia whose molecular etiology is poorly understood. We studied a family with hereditary persistent AF and identified the causative mutation (S140G) in the KCNQ1 (KvLQT1) gene on chromosome 11p15.5. The KCNQ1 gene encodes the pore-forming alpha subunit of the cardiac I(Ks) channel (KCNQ1/KCNE1), the KCNQ1/KCNE2 and the KCNQ1/KCNE3 potassium channels. Functional...
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