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Article

Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation.

European heart journal - 1 May 2013

Christophersen Ingrid E, Olesen Morten S, Liang Bo, Andersen Martin N, Larsen Anders P, Nielsen Jonas B, Haunsø Stig, Olesen Søren-Peter, Tveit Arnljot, Svendsen Jesper H, Schmitt Nicole

Abstract excerpt

AIMS: Genetic factors may be important in the development of atrial fibrillation (AF) in the young. KCNA5 encodes the potassium channel α-subunit KV1.5, which underlies the voltage-gated atrial-specific potassium current IKur. KCNAB2 encodes KVβ2, a β-subunit of KV1.5, which increases IKur. Three studies have identified loss-of-function mutations in KCNA5 in patients with idiopathic AF. We hypothesized that...

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Source

Identifiers

PMID: 23264583
DOI: 10.1093/eurheartj/ehs442

Genes

KCNA5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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