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Article

A novel KCNQ1 missense mutation identified in a patient with juvenile-onset atrial fibrillation causes constitutively open IKs channels.

Heart rhythm - 1 Jan 2014

Hasegawa Kanae, Ohno Seiko, Ashihara Takashi, Itoh Hideki, Ding Wei-Guang, Toyoda Futoshi, Makiyama Takeru, Aoki Hisaaki, Nakamura Yoshihide, Delisle Brian P, Matsuura Hiroshi, Horie Minoru

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) is one of the most common cardiac arrhythmias. In some patients, the disease is inheritable; however, hereditary aspects of AF remain not fully elucidated. OBJECTIVE: The purpose of this study was to identify genetic backgrounds that contribute to juvenile-ons...

Read the complete abstract on PubMed

Topics

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Share to Atrial Fibrillation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to KCNQ1 Potassium Channel

Share to Mutation, Missense

Share to Patch-Clamp Techniques

Share to Potassium Channels, Voltage-Gated

Source

Identifiers

PMID: 24096004
DOI: 10.1016/j.hrthm.2013.09.073

Genes

KCNQ1
KCNJ2
KCNH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24096004-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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