Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gain-of-function mutations in potassium channel subunit KCNE2 associated with early-onset lone atrial fibrillation.

Biomarkers in medicine - 1 Jan 2014

Nielsen Jonas Bille, Bentzen Bo Hjorth, Olesen Morten Salling, David Jens-Peter, Olesen Søren-Peter, Haunsø Stig, Svendsen Jesper Hastrup, Schmitt Nicole

Abstract excerpt

AIMS: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Disturbances in cardiac potassium conductance are considered as one of the disease mechanisms in AF. We aimed to investigate if mutations in potassium-channel β-subunits KCNE2 and KCNE3 are associated with early-onset lone AF. METHODS & RESULTS: The coding regions of KCNE2 and KCNE3 were bidirectionally sequenced in 192 unrelated patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atrial Fibrillation
Share to Blood Pressure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CHO Cells

Share to Cricetinae

Share to Cricetulus

Share to KCNQ1 Potassium Channel

Share to Microscopy, Confocal

Share to Potassium Channels, Voltage-Gated

Source

Identifiers

PMID: 24796621
DOI: 10.2217/bmm.13.137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gain-of-function mutations in potassium channel subunit KCNE2 associated with early-onset lone atrial fibrillation.PMID 24796621Read ↗

Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation.Semantic proximity Read ↗

A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation.Semantic proximity Read ↗

KCNE3 mutation V17M identified in a patient with lone atrial fibrillation.Semantic proximity Read ↗

IKs Gain- and Loss-of-Function in Early-Onset Lone Atrial Fibrillation.Semantic proximity Read ↗

Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation.Semantic proximity Read ↗

Identification of a KCNE2 Gain-of-Function Mutation in Patients with Familial Atrial FibrillationSemantic proximity Read ↗

Arrhythmogenic KCNE gene variants: current knowledge and future challengesSemantic proximity Read ↗

Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation.Semantic proximity Read ↗

Genetic aspects of lone atrial fibrillation: what do we know?Semantic proximity Read ↗

Screening of KCNN3 in patients with early-onset lone atrial fibrillation.Semantic proximity Read ↗

High prevalence of long QT syndrome-associated SCN5A variants in patients with early-onset lone atrial fibrillation.Semantic proximity Read ↗

Deep sequencing of atrial fibrillation patients with mitral valve regurgitation shows no evidence of mosaicism but reveals novel rare germline variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.