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The Mitochondrial Uncoupling Protein-2 Promotes Chemoresistance in Cancer Cells

15 Apr 2008

Abstract excerpt

Cancer cells acquire drug resistance as a result of selection pressure dictated by unfavorable microenvironments. This survival process is facilitated through efficient control of oxidative stress originating from mitochondria that typically initiates programmed cell death. We show this critical adaptive response in cancer cells to be linked to uncoupling protein-2 (UCP2), a mitochondrial suppressor of reactive...

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PMID: 18413749
DOI: 10.1158/0008-5472.can-08-0053

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