Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced DDB2 Expression Protects Mice from Carcinogenic Effects of Chronic UV-B Irradiation

15 Nov 2005

Abstract excerpt

UV-damaged DNA-binding protein (UV-DDB) is essential for global genome repair (GGR) of UV-induced cyclobutane pyrimidine dimers (CPD). Unlike human cells, rodent epidermal cells are deficient in GGR of CPDs and express a subunit of UV-DDB, DDB2, at a low level. In this study, we generated mice (K14-DDB2) ectopically expressing mouse DDB2 at elevated levels. Enhanced expression of DDB2 both delayed the onset of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer Research and Treatments
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16288018
DOI: 10.1158/0008-5472.can-05-2295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced DDB2 Expression Protects Mice from Carcinogenic Effects of Chronic UV-B IrradiationPMID 16288018Read ↗

Tumor-prone phenotype of the DDB2-deficient mice.Semantic proximity Read ↗

DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogenSemantic proximity Read ↗

p53 Binds and Activates the Xeroderma Pigmentosum <i>DDB2</i> Gene in Humans but Not MiceSemantic proximity Read ↗

Emerging Roles of DDB2 in CancerSemantic proximity Read ↗

Impact of global genome repair versus transcription-coupled repair on ultraviolet carcinogenesis in hairless mice.Semantic proximity Read ↗

Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer.Semantic proximity Read ↗

Epigenetic remodeling during UV exposure: high resolution analysis of histone post-translational modifications in a DNA binding protein 2 mutant model.Semantic proximity Read ↗

Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition.Semantic proximity Read ↗

Human papillomavirus mediated inhibition of DNA damage sensing and repair drives skin carcinogenesisSemantic proximity Read ↗

DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA.Semantic proximity Read ↗

Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes.Semantic proximity Read ↗

Frequent recovery of triplet mutations in UVB-exposed skin epidermis of Xpc-knockout mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.