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Article

Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels.

Journal of neurochemistry - 1 Jun 2004

de Bilbao Fabienne, Arsenijevic Denis, Vallet Philippe, Hjelle Ole Petter, Ottersen Ole Petter, Bouras Constantin, Raffin Yvette, Abou Karin, Langhans Wolfgang, Collins Sheila, Plamondon Julie, Alves-Guerra Marie-Clotilde, Haguenauer Anne, Garcia Irene, Richard Denis, Ricquier Daniel, Giannakopoulos Panteleimon

Abstract excerpt

Uncoupling protein 2 (UCP2) is suggested to be a regulator of reactive oxygen species production in mitochondria. We performed a detailed study of brain injury, including regional and cellular distribution of UCP2 mRNA, as well as measures of oxidative stress markers following permanent middle cerebral artery occlusion in UCP2 knockout (KO) and wild-type (WT) mice. Three days post ischemia, there was a massive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15147521
DOI: 10.1111/j.1471-4159.2004.02432.x

Genes

UCP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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