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Article

Methyl-CpG binding-protein 2 function in cholinergic neurons mediates cardiac arrhythmogenesis.

Human molecular genetics - 15 Nov 2016

Herrera José A, Ward Christopher S, Wehrens Xander H T, Neul Jeffrey L

Abstract excerpt

Sudden unexpected death occurs in one quarter of deaths in Rett Syndrome (RTT), a neurodevelopmental disorder caused by mutations in Methyl-CpG-binding protein 2 (MECP2). People with RTT show a variety of autonomic nervous system (ANS) abnormalities and mouse models show similar problems including QTc interval prolongation and hypothermia. To explore the role of cardiac problems in sudden death in RTT, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28159985
DOI: 10.1093/hmg/ddw326
PMCID: PMC6078594

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Methyl-CpG binding-protein 2 function in cholinergic neurons mediates cardiac arrhythmogenesis.PMID 28159985Read ↗

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