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Article

The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei.

Cell - 17 May 2002

Harmar Anthony J, Marston Hugh M, Shen Sanbing, Spratt Christopher, West Katrine M, Sheward W John, Morrison Christine F, Dorin Julia R, Piggins Hugh D, Reubi Jean Claude, Kelly John S, Maywood Elizabeth S, Hastings Michael H

Abstract excerpt

The neuropeptides pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are implicated in the photic entrainment of circadian rhythms in the suprachiasmatic nuclei (SCN). We now report that mice carrying a null mutation of the VPAC(2) receptor for VIP and PACAP (Vipr2(-/-)) are incapable of sustaining normal circadian rhythms of rest/activity behavior. These mice also...

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Identifiers

PMID: 12086606
DOI: 10.1016/s0092-8674(02)00736-5

Genes

VIP
AVP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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