Article
Association analysis of genetic polymorphisms in genes related to sunitinib pharmacokinetics, specifically clearance of sunitinib and SU12662.
Clinical pharmacology and therapeutics - 1 Jul 2014
Diekstra M H M, Klümpen H J, Lolkema M P J K, Yu H, Kloth J S L, Gelderblom H, van Schaik R H N, Gurney H, Swen J J, Huitema A D R, Steeghs N, Mathijssen R H J
Abstract excerpt
Interpatient variability in the pharmacokinetics (PK) of sunitinib is high. Single nucleotide polymorphisms (SNPs) in PK candidate genes have been associated with the efficacy and toxicity of sunitinib, but whether these SNPs truly affect the PK of sunitinib remains to be elucidated. This multicenter study involving 114 patients investigated whether these SNPs and haplotypes in genes encoding metabolizing enzymes...
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