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Article

BSA and ABCB1 polymorphism affect the pharmacokinetics of sunitinib and its active metabolite in Asian mRCC patients receiving an attenuated sunitinib dosing regimen.

Cancer chemotherapy and pharmacology - 1 Sept 2016

Chae Jung-Woo, Teo Yi Ling, Ho Han Kiat, Lee Jaeyeon, Back Hyun-Moon, Yun Hwi-Yeol, Karlsson Mats O, Kwon Kwang-Il, Chan Alexandre

Abstract excerpt

PURPOSE: An attenuated dosing (AD) sunitinib regimen of 37.5 mg daily has been suggested to reduce the toxicity reported with the standard dosing regimen to metastatic renal cell carcinoma (mRCC) patients. The aim of this study was to characterize the population pharmacokinetic (PK) properties of sunitinib and SU12662, the active metabolite, in patients receiving the AD regimen and to ascertain significant...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27485537
DOI: 10.1007/s00280-016-3104-9

Genes

ABCB1
TTL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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